The prefrontal cortex is responsible for executive functions like decision-making and impulse control, which are impaired in addiction.

The prefrontal cortex acts as the brain’s control center. It helps us plan, weigh consequences, and regulate impulses. In addiction, this area is compromised, weakening a person’s ability to resist urges and make rational decisions about drug use. This impairment makes it hard to stop despite knowing the harmful effects. Moreover, this area is the last part of the brain to fully mature, which partly explains why adolescents are especially vulnerable to addiction.