From: The Hijacked Reward: How Cocaine Remakes the Brain and Body
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Cocaine use severely constricts blood vessels, drastically increasing the risk of heart attacks and strokes.

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Cocaine acts as a powerful stimulant that triggers the release of stress hormones, causing immediate constriction of the blood vessels. At the same time, it forces the heart to beat much faster and with greater intensity. This dangerous combination—forcing a hyperactive heart to pump blood through severely narrowed channels—skyrockets blood pressure. This can lead to acute medical emergencies such as heart attacks, strokes, or aortic ruptures, even in young, otherwise healthy individuals.

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The Hijacked Reward: How Cocaine Remakes the Brain and Body
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