From a physiological standpoint, type 2 diabetes disrupts the normal balance between anabolic‑abolic pathways, besides impaired glucose uptake, also known as the body's storage hormone and catabolic hormones like glucagon and cortisol. Insulin resistance reduces glucose entry into muscle and fat cells, while the liver continues to produce glucose, raising blood sugar. To compensate, the pancreas secretes more insulin, which paradoxically promotes fat storage in some tissues but simultaneously triggers lipolysis and proteolysis in others. The net effect is a futile cycle where calories are burned rather than stored, especially when glycemic control is poor. This explains why patients may eat more yet lose weight or fail to gain.